Modeling diffusional transport in the interphase cell nucleus
نویسندگان
چکیده
منابع مشابه
Interphase chromosomes undergo constrained diffusional motion in living cells
BACKGROUND Structural studies of fixed cells have revealed that interphase chromosomes are highly organized into specific arrangements in the nucleus, and have led to a picture of the nucleus as a static structure with immobile chromosomes held in fixed positions, an impression apparently confirmed by recent photobleaching studies. Functional studies of chromosome behavior, however, suggest tha...
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In the living interphase nucleus no chromosomal structures are visible. Yet in the injured cell and after treatment with most histological fixatives chromatin structures become apparent. Under certain conditions this appearance of structure in the living interphase nucleus is reversible. We have found that this change in the interphase nucleus is the result of a change in the state of the chrom...
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NuMA is an essential protein for the formation of spindle poles in mitosis. During interphase, NuMA is transported into the nucleus where it resides until prometaphase of the next mitotic cycle. We tested for a potential function of NuMA in interphase nuclei that were assembled from human sperm DNA using frog egg extract immunodepleted of NuMA. Despite the absence of NuMA, nuclei formed without...
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The metabolism of a living cell requires a permanent transfer of molecules throughout the cell and beyond its bounds. Within cell nuclei, molecules are predominantly driven by diffusion, which is influenced by the chromatin network. We propose a quantity related to the pair correlation function to measure the diffusion-relevant clumpiness of chromatin. Using Monte Carlo lattice simulations, we ...
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In this article, some views on the nature of incoherent interphase interfaces, and their role in the nucleation and growth processes governing the evolution of microstructure in solid-state diffusional transformations (reconstructive transformations), are explored. It is argued that essentially incoherent interfaces can be involved in the initiation and propagation of polymorphic transformation...
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ژورنال
عنوان ژورنال: The Journal of Chemical Physics
سال: 2007
ISSN: 0021-9606,1089-7690
DOI: 10.1063/1.2753158